Heart disease breakthrough as team grows human blood vessels in lab
Scientists grow human blood vessels in the lab in ‘game changing’ breakthrough for disease research
- Three-dimensional human blood vessel ‘organoids’ were grown in a petri dish
- Could have a dramatic effect on a host of vascular problems, including diabetes
Scientists have managed to grow ‘perfect’ human blood vessels in the lab for the first time.
The breakthrough could have a dramatic effect on research into a host of vascular problems, including diabetes.
It will allow researchers to study and test new drugs far more easily.
A 3D reconstruction of one of the blood vessel ‘organoids’ the team was able to grow from stem cells.
‘Being able to build human blood vessels as organoids from stem cells is a game changer,’ said the study’s senior author Josef Penninger, director of the Life Sciences Institute at the University of British Columbia.
‘Every single organ in our body is linked with the circulatory system.
‘This could potentially allow researchers to unravel the causes and treatments for a variety of vascular diseases, from Alzheimer’s disease, cardiovascular diseases, wound healing problems, stroke, cancer and, of course, diabetes.’
Penninger and his colleagues developed a method to grow three-dimensional human blood vessel ‘organoids’ grown in a petri dish.
An organoid is a three-dimensional structure grown from stem cells that mimics an organ and can be used to study aspects of that organ in a petri dish.
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Diabetic blood vessel changes in patients and human vascular organoids. The basement membrane (green) around the blood vessels (red) is massively enlarged in diabetic patients (white arrows). The human vascular organoids that were made ‘diabetic’ in the laboratory can now be used as diabetic model to identify new treatments.
These so-called ‘vascular organoids’ can be cultivated using stem cells in the lab, strikingly mimicking the structure and function of real human blood vessels.
When researchers transplanted the blood vessel organoids into mice, they found that they developed into perfectly functional human blood vessels including arteries and capillaries.
The discovery illustrates that it is possible to not only engineer blood vessel organoids from human stem cells in a dish, but also to grow a functional human vascular system in another species.
The breakthrough technology, revealed in the journal Natural, also revealed a new pathway to potentially prevent changes to blood vessels—a major cause of death and morbidity among those with diabetes.
The researchers exposed their blood vessel organoids to a ‘diabetic’ environment in a petri dish.
‘Surprisingly, we could observe a massive expansion of the basement membrane in the vascular organoids,’ said Wimmer.
‘This typical thickening of the basement membrane is strikingly similar to the vascular damage seen in diabetic patients.’
The researchers then searched for chemical compounds that could block thickening of the blood vessel walls.
They found none of the current anti-diabetic medications had any positive effects on these blood vessel defects.
THE DIABETES TIMBOMB
Diabetes affects an estimated 420 million people worldwide.
Many diabetic symptoms are the result of changes in blood vessels that result in impaired blood circulation and oxygen supply of tissues.
Despite its prevalence, very little is known about the vascular changes arising from diabetes.
One feature of diabetes is that blood vessels show an abnormal thickening of the basement membrane.
As a result, the delivery of oxygen and nutrients to cells and tissues is strongly impaired, causing a multitude of health problems, such as kidney failure, heart attacks, strokes, blindness and peripheral artery disease, leading to amputations.
However, they discovered that an inhibitor of γ-secretase, a type of enzyme in the body, prevented the thickening of the blood vessel walls, suggesting it could be helpful in treating diabetes.
The researchers say the findings could allow them to identify underlying causes of vascular disease, and to potentially develop and test new treatments for patients with diabetes.
‘What is so exciting about our work is that we were successful in making real human blood vessels out of stem cells,’ said Reiner Wimmer, the study’s first author and a postdoctoral research fellow at IMBA.
‘Our organoids resemble human capillaries to a great extent, even on a molecular level, and we can now use them to study blood vessel diseases directly on human tissue.’
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